英国剑桥，中国上海，2020.12.01：dafabe888手机版登录（上海）有限公司与Horizon Discovery集团有限公司今日共同宣布，双方签署两项关于GS敲除CHO K1细胞株的商业化使用授权。Horizon公司在构建工程细胞株中全球领先，其提供的谷氨酰胺转移酶稳定敲除（GS-/-）的中国仓鼠卵巢细胞（CHO）K1细胞株表达平台，将在dafabe888手机版登录的抗体药临床前项目开发、客户和合作方生物治疗产品的临床开发和商业化生产、以及一体化解决方案中发挥重要作用。
Horizon独有的GS-/- CHO K1细胞株和表达工艺有很多成功的生物医药开发案例，不仅涵盖以研究目的为主的瞬时表达，也涵盖临床和商业生产用生物制剂的稳定细胞株的开发，其也在新型多特异性抗体或其它复杂结构的分子中得到了应用。Horizon授权 CHOSOURCE表达系统于制药公司、生物技术公司、生物仿制药公司和合同生产企业等多种类型的机构，广泛助力新药的研发进程。
Zyme Communications (贸易、区域化媒体)
Tel: +44 (0)7811 996 942
Tel: +86 400 821 0776
Sanyou signs two commercial-use licenses for Horizon’s gene-edited CHO-K1 GS knockout cell line, for use in biotherapeutic pipeline development and contract research services
Cambridge, UK, and Shanghai, China, 01 December 2020: Horizon Discovery Group plc (LSE: HZD) (“Horizon”, “the Company” or “the Group”), a global leader in the application of gene editing and gene modulation for cell line engineering, today announced that it has granted two commercial licenses for its cGMP-compliant CHOSOURCE™ platform to Sanyou Biopharmaceuticals Co., Ltd. (“Sanyou”), a leading biotechnology company focused on research, development and providing integrated solutions for innovative antibody drug developments. Sanyou will use Horizon’s gene-edited Glutamine Synthetase (GS) knockout Chinese Hamster Ovary (CHO) K1 cell line for the development of pre-clinical antibody drug projects and to support the clinical development and commercialization of its customers’ human biotherapeutic products as well as offering the platform through its contract research services.
“Sanyou is a leading biotechnology company with extensive experience in early stage drug discovery, IND filing and clinical trial management. The Company has established an integrated innovative antibody drug R&D laboratory and we are pleased CHOSOURCE has been selected tosupport its biotherapeutic pipeline and contract research services offering,” commented Jesús Zurdo, Global Head Bioproduction Business Unit, Horizon Discovery. “Horizonis committed to supporting innovative organizations of all sizes to empower biotherapeutic production using our expression platform. We are proud to have licensed CHOSOURCE to over 80 organizations, from non-for-profit and early stage startups to clinical stage biotechnology and large pharmaceutical companies, and helped enable at least 8 biotherapeutics expressed in these cells to progressinto clinical trials.”
Dr. David Lang, CEO, Sanyou Biopharmaceuticals Co., Ltd., said: “Horizon’s CHOSOURCE facilitates the development of stable cell lines for the expression of antibodies and other recombinant proteins, and is recognized in the industry and by regulators for high yield manufacturing. This robust platform will be key in enabling us to generate stable cell lines for the development of antibody drugs, diagnostic products and cell therapy-related components, and allow us to provide a stronger one-stop solution to our clients with IND ready projects through our contract research services and pipeline-enriching collaborations.”
Horizon’s proprietary GS knockout CHO cell line and protocols have a successful track record in the discovery and development of biopharmaceuticals, from transient expression for research applications to the development of stable cell lines for clinical and commercial production of biotherapeutics, including novel multi-specific and complex molecular architectures. The Company licenses its CHOSOURCE expression system to pharmaceutical, biotechnology, and biosimilar companies, as well as contract manufacturing organizations.
For further information on Horizon’s CHO expression system please visit:
For further information from Horizon Discovery Group plc, please contact:
Zyme Communications (Trade and Regional Media)
Tel: +44 (0)7811 996 942
For further information from Sanyou Biopharmaceuticals Co., Ltd., please contact:
Strategic Development Department
Tel: +86 400 821 0776
Built upon more than a decade of experience in the engineering of cell lines, Horizon offers an unmatched portfolio of tools and services to help scientists gain a greater understanding of gene function, identify genetic drivers behind human disease, deliver biotherapeutics, cellular and gene therapies for precision medicine as well as develop and validate diagnostic workflows.
Horizon’s solutions enable almost any gene to be altered, or its function modulated, in human and other mammalian cell lines.
The Company’s customers include many of the world’s foremost academic institutes, global pharmaceutical and biotechnology companies as well as clinical diagnostic laboratories. Insight into the challenges faced by these organizations enables the company to focus efforts on development of innovative solutions that not only differentiate the company’s offering, but also fuel development of the next wave of precision medicines.
Horizon is headquartered in Cambridge, UK with offices in USA and Japan. The Group is listed on the London Stock Exchange's AIM market under the ticker HZD.
About Horizon's CHOSOURCE™ platform
Horizon’s proprietary CHOSOURCE™ platform, consisting of a GS knockout CHO K1 cell line combined with a dual promoter expression vector, is now established as an industry standard for host cell line development, facilitating cell line selection and optimization of costs and production processes. A comprehensive cell line history and a clear intellectual property position ensure freedom to operate in biotherapeutic production. Horizon’s robust CHO GS knockout host cell line provides an optimal expression system with an excellent performance record.
Sanyou is committed to building world-leading antibody drug discovery and development platforms of high-quality, high-throughput, integrated R&D and value transformation. Sanyou is dedicated in constructing a business ecosystem for therapeutic, R&D and diagnostic products and services, and collaborating with global biopharmaceutical, diagnostic, R&D companies to open a new era forthe diagnosis and treatment of human diseases.
Since Sanyou’s founding five years ago, Sanyou has been growing rapidly. As of November 2020, Sanyou has a professional team of more than 150 employees, of which more than 70% hold a PhD or master degree, and this team is deeply experienced in R&D and industrialization of innovative drugs. Sanyou has established an integrated R&D laboratory of several thousands of squaremeters with advanced facilities in Caohejing Hi-Tech Park in Shanghai. Thelaboratory have 10 functional modules and more than 40 core technology platforms, led by a series of super-trillion phage display antibody libraries,and followed by a full range of essential R&D platforms for innovative antibody drug discovery, antibody engineering, in vitro and in vivo efficacy screening, pharmaceutical properties analysis, cell line construction, andprocess development. Sanyou continues to provide new technologies, newproducts, services and solutions of "best quality, fastest speed and lowest cost". Sanyou has established friendly business relationships withmore than 100 pharmaceutical companies, drug development organizations anddiagnostic product development companies around the world.
“Excellenceand innovation, pursuit of dreams, striving and evolving, for the benefit ofpatients”, holding these principles and beliefs, Sanyou looks forward toworking with our customers and partners to build a long-term synergistic growth ecosystem and a healthy society.